Can African American take lisinopril?
However, the increased stroke risk associated with lisinopril was experienced among African American but not non-African American patients. ALLHAT did not permit combination therapy with ACE inhibitors plus diuretics; therefore, the benefits of such regimens in this patient population could not be assessed.
Which blood pressure medication is best for African American?
Calcium channel blockers, namely amlodipine (Norvasc), or the less often prescribed felodipine, are also recommended as first choice to control blood pressure, specifically in African Americans.
Why are ACE inhibitors bad for blacks?
Angiotensin converting enzyme (ACE) inhibitors have been avoided as an initial therapeutic option in the treatment of hypertension in African-Americans. A major reason for this has been the widespread perception of clinicians that these agents have poor blood pressure (BP) lowering efficacy in this population.
Why are ACE inhibitors not first line for black people?
Angiotensin converting enzyme (ACE) inhibitors, β blockers, and angiotensin receptor antagonists are generally less effective as monotherapy in black hypertensives,22,23 because of the tendency towards a low renin state and a lower cardiac output, with increased peripheral resistance.
Why does lisinopril cause angioedema in African American?
The mechanism of ACE inhibitor-associated angioedema is not known, although a plausible mechanism involves the vasoactive peptide bradykinin [6, 7]. The increased risk in black patients may be related to racial differences in the kallikrein-kinin system and increased sensitivity to bradykinin .
Are beta blockers safe for African American?
Abstract. It has been reported that beta blockers are not effective antihypertensives in black populations. A review of the literature revealed that, for the most part, studies drawing this conclusion were of small sample size, lacked controls, and did not represent the demographics of the US black population.
Can black people take metoprolol?
In a subsequent secondary analysis of data from the AASK study, Juraschek et al showed that metoprolol significantly increased serum uric acid in African-American adults. It is known that hyperuricemia (> 6 mg/dL) can cause a decline in kidney function.
Why African Americans should not take lisinopril?
However, lisinopril was associated with an increased risk for heart failure (relative risk [RR] for African Americans=1.32; 95% CI, 1.11–1.58) and stroke (RR for African Americans=1.4; 95% CI, 1.17–1.68), and amlodipine was associated with a higher risk of heart failure (RR in African Americans=1.47; 95% CI, 1.24–1.74) …
Why should African Americans not take lisinopril?
Which medications may be less effective in the African American population?
ACE inhibitors seem to be less effective in the treatment of black patients with heart failure compared with white patients. This may be due to low pre-existing activity of the renin-angiotensin system in blacks.
Why is lisinopril not recommended for African Americans?
How does lisinopril affect African Americans?
Angioedema (swelling) is a potential problem that may occur in some people taking lisinopril. As with other ACE inhibitors , this drug may cause angioedema of the head and neck, including the tongue, lips, eyes, or throat. This occurs more frequently in African Americans.
What are the long term effects of taking lisinopril?
Long term side effects of lisinopril can occur, especially if someone takes too much for too long. These include: Swelling in the face, throat, hands, feet, ankles, or lower legs. Difficulty breathing or swallowing, which can indicate a serious allergic reaction.
How bad are the side effects if I stop taking lisinopril?
Just like any other drug, using Lisinopril has a number of side effects such as chills, dark urine, difficulty swallowing or breathing, abdominal pain, bloating and vomiting. Furthermore, one cannot stop taking Lisinopril all of sudden.
What are the benefits of taking lisinopril?
Doctors will often prescribe lisinopril for blood pressure in patients who have experienced a life threatening cardiac event. One of the benefits of taking this medication is that it can, when used correctly, lower a patient’s blood pressure and decrease the amount of work the heart needs to do to pump blood through the body.