What are antifibrotic drugs?

What are antifibrotic drugs?

Two antifibrotic therapies have been approved for the treatment of IPF: nintedanib and pirfenidone. These drugs slow decline in lung function and reduce the risk of acute respiratory deteriorations, which are associated with very high morbidity and mortality.

Is pirfenidone an antifibrotic?

Pirfenidone is an antifibrotic agent that is potentially effective for IPF treatment. Preclinical studies have been reported using experimental animal models, which revealed inhibitory effects pn profibrotic and proinflammatory cytokines.

What is nintedanib drug used for?

Generic Name: nintedanib This medication is used to treat certain types of lung disease (idiopathic pulmonary fibrosis- IPF, interstitial lung disease). Both types of lung disease scar and stiffen your lungs, making it hard to breathe. Nintedanib may help slow down the worsening of your lung disease.

Is OFEV an antifibrotic?

Ofev (nintedanib) is an anti-fibrotic medicine marketed by Boehringer Ingelheim that was approved for the treatment of idiopathic pulmonary fibrosis (IPF) in the U.S. in 2014 and in Europe in 2015.

What class of drug is pirfenidone?

Pirfenidone is in a class of medications called pyridones. It is not known exactly how pirfenidone works to treat idiopathic pulmonary fibrosis.

Is Pirfenex an immunosuppressant?

Pirfenidone, an immunosuppressant, has been authorised in the European Union for the treatment of mild to moderate idiopathic pulmonary fibrosis. Clinical evaluation is based on two double-blind randomised placebo-controlled trials lasting 72 weeks in a total of 779 patients.

What type of drug is pirfenidone?

Pirfenidone is used for the treatment of idiopathic pulmonary fibrosis (scarring of the lungs with an unknown cause). Pirfenidone is in a class of medications called pyridones. It is not known exactly how pirfenidone works to treat idiopathic pulmonary fibrosis.

Is pirfenidone an antibiotic?

Using the microplate Alamar blue assay (26), pirfenidone was observed to possess no antibacterial activity at concentrations as high as 100 μg/ml against Escherichia coli, Mycobacterium smegmatis, or Mtb.

Do you need an antifibrotic agent for liver disease?

Therefore, highly efficient and specific antifibrotic agents are needed that can address advanced fibrosis, i.e., the detrimental downstream result of all chronic liver diseases.

Which is the best antifibrotic agent for IPF?

Antifibrotic agents, such as pirfenidone and nintedanib, have been shown to be effective in slowing decline of FVC in IPF (Richeldi et al., 2014; King et al., 2014; Noble et al., 2016 ).

Are there any anti fibrotic therapies for lung disease?

There is growing enthusiasm to study anti-fibrotic therapy for inevitable lung fibrosis, and clinical trials are underway using currently FDA-approved anti-fibrotic therapies.

Which is an adjunctive use of an antifibrotic agent?

An important adjunctive use of antifibrotic agents involves salvaging failed or failing filtration blebs. Late failure of a bleb with a patent fistula after trabeculectomy usually indicates a cystoid, encapsulated, or flattened bleb.