What is the most likely cause of skin rashes in patients taking EGFR inhibitors?

What is the most likely cause of skin rashes in patients taking EGFR inhibitors?

Acneiform rash is the most common side effect of epidermal growth factor receptor (EGFR) inhibitors (EGFRis). EGFR belongs to a family (ErbB) of tyrosine kinase receptors which regulate tumor cell differentiation, survival, and proliferation.

How do you treat Papulopustular rash?

The typical papulopustular rash occurs within 1 to 3 weeks of starting treatment, and is fully developed at weeks 3 to 5. Usually, these skin toxicities are treated with both topical (moisturizers, emollients, topical antibiotics/steroids) and/or systemic measures (oral antibiotics, steroids and antihistaminic drugs).

What drugs cause acneiform eruptions?

There are many causes for acneiform eruptions including exposure to halogenated aromatic hydrocarbons and the use of antibiotics like macrolides and penicillin. Other drugs that can also induce acneiform eruptions include nystatin, isoniazid, corticotropin, naproxen, and hydroxychloroquine.

Which is the best description of an acneiform rash?

Definition: Acneiform rash (‘rash’; also referred to as acneiform eruption, acne-like rash, papulopustular rash or Folliculitis) is characterised by Follicular, papulopustular eruptions confined to the seborrheic areas, frequently localised to the face, scalp, upper chest and back.1,2.

What kind of rash is an acne like rash?

Skin Changes – Acneiform Rash. Definition: Acneiform rash (‘rash’; also referred to as acneiform eruption, acne-like rash, papulopustular rash or Folliculitis) is characterised by Follicular, papulopustular eruptions confined to the seborrheic areas, frequently localised to the face, scalp, upper chest and back.

When do acneiform eruptions occur on the face?

An inflammatory disease of the sebaceous follicles of the skin, marked by comedones, papules, and pustules. It is exceptionally common in puberty and adolescence. Acne usually affects the face, chest, back, and shoulders.

What does NCI CTCAE mean for Grade 3 acneiform rash?

The largely corresponding NCI-CTCAE v4.03 definition for ‘Grade 3 Acneiform rash’ reads: Papules and/or Pustules covering >30% BSA, which may or may not be associated with symptoms of Pruritus or tenderness; limiting self care ADL (refers to bathing, dressing and undressing, feeding self, using the toilet, taking medications,…