Which cells secrete CCL3?
Which cells secrete CCL3?
A variety of cells have been shown to secrete CCL3 including lymphocytes, fibroblasts, and epithelial cells, as well as both resident and recruited monocytes and macrophages [25,26]. A potent chemokine for lymphocytes and monocytes, CCL3 binds to CCR1, CCR4 and CCR5 receptors on T cells, DCs, B cells, and eosinophils.
What is the function of CCL3?
Function. CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.
What produces CCL3?
6 CCL3 (MIP-1α) and CCL4 (MIP-1β)—Chromosome 17, MIP Subregion. CCL3 is expressed constitutively in the bone marrow, including by osteoblasts, and is induced during inflammation.
What is CCl3 and CCL4?
CCL3 and CCL4, previously called macrophage inflammatory protein-1α (MIP-1α) and MIP-1β, are chemokines of the CC subfamily and inducible in a number of haematopoietic cells, particularly those involved in adaptive immune responses (macrophages, dendritic cells, and B and T lymphocytes)(Eberlein, et al 2010).
What is the name of CCl3?
Trichloromethyl radical
Trichloromethyl radical
| PubChem CID | 122980 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | CCl3 |
| Synonyms | Trichloromethyl radical Trichloromethyl free radical Trichloromethyl 3170-80-7 Methyl, trichloro- More… |
| Molecular Weight | 118.37 |
What is CCl3 chemistry?
Trichloromethyl radical | CCl3 – PubChem.
What protein is produced by macrophages?
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now (according to the new nomenclature) officially named CCL3 and CCL4, respectively.
How is CCL3 expressed in bone marrow cells?
CCL3 (macrophage inflammatory protein-1α, MIP-1α) is a direct stimulator of osteoclastogenesis that is expressed in bone and bone marrow cells [268–271] by a mechanism that is proposed to be independent of RANK activation [272]. In addition, it can enhance RANKL expression by stromal cells and osteoblasts in the bone microenvironment [273].
What is the role of CCL3 in the murine response?
CCL3, also known as macrophage inflammatory protein 1-alpha (MIP-1α), is critical in the murine response to cytomegalovirus infection.
What causes the expression of CCL3 and CCl4?
Bacterial toxins, viral infections, TNFα, IFN-γ, IL-1β, and IL-6 are some of the stimuli that induce the expression of CCL3 and/or CCL4 in vitro from multiple cell types including monocytes/macrophages, DCs, and epithelial cells.
What happens to mice that are CCL3 deficient?
Mice treated with monoclonal antibodies against CCL3 or that are CCL3-deficient have an impaired inflammatory response and decreased pathology from viral infections, decreased survival after infection with Cryptococcus neoformans, delayed allograft rejection, and attenuated development of experimental autoimmune encephalitis.