Why chloroquine is contraindicated in pregnancy?

Why chloroquine is contraindicated in pregnancy?

You should not avoid taking chloroquine because you are pregnant. The risk of harm to you and your baby from malaria is likely to be far greater than any potential risk from taking chloroquine.

What is the preferred treatment in pregnant patient with malaria?

Uncomplicated malaria in pregnancy Currently, quinine and clindamycin is the recommended treatment for women in the first trimester of pregnancy31. In many places, clindamycin is unavailable, and quinine monotherapy is prescribed.

Is chloroquine safe in first trimester of pregnancy?

Pregnancies exposed to quinine or chloroquine and carried to term did not have increased rates of congenital abnormality, stillbirth or low birthweight. These results suggest that therapeutic doses of quinine and chloroquine are safe to use in the first trimester of pregnancy.

What is the drug of choice for chloroquine resistant malaria?

These results indicate that berberine is more effective in clearing the parasite than both tetracycline and cotrimoxazole, and that the combination of pyrimethamine and berberine gives the best results for chloroquine resistant malaria.

What are the contraindications of chloroquine?

Who should not take CHLOROQUINE PHOSPHATE?

  • low blood sugar.
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • low amount of magnesium in the blood.
  • low amount of potassium in the blood.
  • porphyria.
  • anemia.
  • low levels of white blood cells.
  • alcoholism.

Which antimalarial drug is contraindicated in pregnancy?

Antimalarial drugs that should not be used in pregnancy including (1) halofantrine, (2) tetracycline/doxycycline, and (3) primaquine. There are few studies in humans on the pharmacokinetics, safety and efficacy of antimalarials in pregnancy.

Can you treat malaria in pregnancy?

Malaria is associated with an increased risk of abortion, stillbirth, and low birth weight. The World Health Organization (WHO) now recommends that all women in the second or third trimester of pregnancy who have uncomplicated P. falciparum malaria should be treated with artemisinin-based combination therapy.

Is IV artesunate safe in pregnancy?

In two studies comparing intravenous quinine with intravenous artesunate, intravenous artesunate was more efficacious and safe for use in pregnant women. No studies detected an increased risk of miscarriage, stillbirth, or congenital anomalies associated with first trimester exposure to artesunate.

How do you treat chloroquine-resistant falciparum?

Because the other drugs effective against chloroquine-resistant P falciparum may produce uterine stimulation (quinine sulfate) or damage the fetal skeleton (tetracyclines), the pyrimethamine-sulfonamide combination (with folinic acid supplementation) may be the best available choice for the treatment and prophylaxis of …

Which of the following drugs can be used for the treatment of chloroquine-resistant malaria in children?

Artemisinin-based combination therapies (ACTs). This is usually the preferred treatment for chloroquine-resistant malaria. Examples include artemether-lumefantrine (Coartem) and artesunate-mefloquine.