What is the most common site for an epithelioid trophoblastic tumor?
What is the most common site for an epithelioid trophoblastic tumor?
Approximately 30.0% of patients reportedly presented with metastatic disease at diagnosis 3, 5. The uterus is the most common primary site of ETT while the lung is the most common extra-uterine site of metastasis, accounting for 19.0% of cases 19.
Does gestational trophoblastic disease require chemotherapy?
Background. Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy‐related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery.
Can trophoblastic tumors spread?
Placental-site trophoblastic tumor (PSTT). This type of tumor grows slowly, but it can eventually spread to the uterine muscle, nearby blood vessels, and lymph nodes, pelvis, or lungs.
What type of chemotherapy is used for molar pregnancy?
You have treatment with methotrexate as low risk chemotherapy if you have PTD after a molar pregnancy. You have the methotrexate as an injection into a muscle (intramuscularly) every other day. This is usually into one of the large muscles in your leg or your bottom (buttock).
What is placental site nodule?
Placental site nodule (PSN) is a rare benign lesion of the intermediate trophoblast which is thought to represent incomplete involution of the placental implantation site. PSN usually presents as menorrhagia, intermenstrual bleeding or an abnormal Pap smear.
What is the treatment for GTD?
GTD is typically curable, especially when found early. The main treatments for GTD are surgery and/or chemotherapy.
How is gestational trophoblastic treated?
Treatment of recurrent or resistant gestational trophoblastic tumor may include the following: Chemotherapy with one or more anticancer drugs for tumors previously treated with surgery. Combination chemotherapy for tumors previously treated with chemotherapy. Surgery for tumors that do not respond to chemotherapy.
How quickly does choriocarcinoma spread?
Choriocarcinoma can develop some months or even years after pregnancy and can be difficult to diagnose, because it is so unexpected. They can grow quickly and might cause symptoms within a short period of time. They can spread to other parts of the body but are very likely to be cured by chemotherapy treatment.
Can molar pregnancy spread?
In most molar pregnancies, any remaining abnormal tissue in the womb usually dies off. But in a small proportion of women, the tissue can remain and grow further into the lining of the womb and, like a cancer, spread to other areas of the body.
How long is chemo for molar pregnancy?
Doctors administer chemotherapy in cycles of treatment and recovery. These cycles are generally 2–3 weeks long and may repeat for 3–6 months.
Is Methotrexate used for molar pregnancy?
This information is for patients who have been diagnosed with a molar pregnancy (hydatidiform mole) and need to have treatment with methotrexate. What is methotrexate? Methotrexate is a medicine used in chemotherapy which stops the rapid growth of the hydatidiform mole.
Which is the best treatment for a trophoblastic tumor?
Because the biologic behaviours of ETT have been reported to be similar to those of placental site trophoblastic tumor (PSTT), and limited evidence is available for the optimal management of ETT, treatment approaches have been derived from case series and PSTT. Surgery is the primary treatment recommended for ETT with nonmetastatic disease.
Can a placental site trophoblastic tumor be calcified?
Calcification is common in epithelioid trophoblastic tumors, which is unique among all gestational trophoblastic diseases / GTDs; i.e. calcification is NOT present in placental site trophoblastic tumor / PSTT or choriocarcinoma
Is the trophoblast a squamous or chorionic type tumor?
Chorionic type intermediate trophoblast has moderate eosinophilic to clear (glycogen rich) cytoplasm with distinct cell membranes, round nuclei and distinct small nucleoli ETT can replace and reepithelialize endocervical or endometrial surface epithelium and can mimic squamous epithelium
Which is the rarest type of gestational trophoblastic tumor?
Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets.